PREPARATION AND PROPERTIES OF A THERMO-SENSITIVE HYDROGEL BASED ON OXIDIZED SODIUM ALGINATE
一种氧化海藻酸钠基温敏凝胶的制备与性能

A multifunctional macromolecule poly(N-isopropylacrylamide-co-methylacrylate-co-hydrazide)(PNMH) was prepared and used to cross-link oxidized sodium alginate(OSA) to form biodegradable and thermosensitive gels.Thermo-sensitivity and degradable properties of the gels were evaluated by measuring the transmittance at different temperatures and the time dependence of the swelling ratio in phosphate buffered saline,respectively.FTIR and LCRS were applied to characterize the samples.It is showed that gels are cross-linked by the forming of CN bonds.The macromolecule PNMH shows thermo-sensitivity.With increasing PNMH content,the thermo-sensitivity of gels is improved,and degradation time of gels becomes longer.In addition,the PNMH content has great effect on the temperation dependence of swelling and degradation of hydroels.