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过程工程学报 2007
Behavior of Hyaluronic Acid in Electro-Membrane Separation
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Abstract:
An electro-membrane separation technique was introduced to extract hyaluronic acid from fermentation broth. The present studies were focused on the behavior of hyaluronic acid under electrical field and the effects of hyaluronic acid concentration, pH, ion strength and electric current intensity on the extraction. The results show that the extraction rate of hyaluronic acid is proportional to the concentration and the electric current. The electrophoresis mobility of hyaluronic acid is kept constant within pH 7-9, and the extraction of hyaluronic acid is independent of pore size. The separation experiment with fermentation broth shows that hyaluronic acid can be fully separated from proteins in broth.
