Preparation of Gelatin Submicron Particles with Emulsion Method
乳化法明胶亚微米粒子的制备

Gelatin submicron particles were prepared by emulsion chemical cross-linking method using gelatin (type A) as core material and paraffine as oil phase. The morphology and particle size of gelatin submicron particles were observed by scanning electron microscopy (SEM). The effects of gelatin concentration, emulsion stirring speed, emulsion temperature, emulsifier and cross-linking agent on particle size distribution, were investigated. The results show that increasing gelatin concentration, enhancing emulsion and using mixed emulsifier can decrease the gelatin submicron particle diameter using glutaraldehyde as cross-linking agent. In addition, the gelatin submicron particles with an average particle size about 450 nm and an orbicular spheric morphology were produced by using a high emulsion stirring speed of 7000 r/min in the optimum procedure.