Preparation of Uniform Size PLGA Microparticles and Microcapsules by Premix Membrane Emulsification
快速膜乳化法制备粒径均一的PLGA微球和微囊

Glucagon-like peptide-1(GLP-1) loaded poly(lactic-co-glycolic acid)(PLGA) microspheres were prepared by premix membrane emulsification and solvent extraction method.The preparation conditions of PLGA microparticles were optimized with respect to particle size and size distribution.The final optimum conditions were as follows:transmembrane pressure 1000 kPa,transmembrane pass 3,concentration of poly(vinyl alcohol)(PVA) in external water phase 19 g/L and volume ratio of oil phase to external water phase 1:5.T...