Preparation of Molecularly Imprinted Polymer for Sulpiride and Its Adsorption Characteristics
舒必利分子印迹聚合物的制备及其吸附性能

Using sulpiride(SUL) as template,methacrylic acid(MAA) as function monomer,and ethyleneglycol dimethacrylate(EDMA) as cross linker,a molecularly imprinted polymer(MIP) was synthesized by bulk polymerization.Static adsorption and isothermal adsorption experiments were performed to study the influential factors on adsorption properties of the MIP to SUL by UV,FT-IR and SEM analysis.Adsorption mechanism of the MIP was also analyzed.The results showed that its best imprinting effect on SUL was observed when the volume of acetonitrile was 6 mL,molar ratio of SUL to MAA 1 to 4,and methanol-acetic acid(9:1,φ) used as eluting agent.The MIP offered uniform,loose and porous structure with 79.12 μmol/g of maximum adsorption capacity and 3.76 of imprinted factor for SUL.The main recognition sites of MIP were cavities caused by three types of amino groups on amide,benzsulfamide and 1-methylpyrrolidine in molecular structure.The MIP had better specific adsorption and exhibited good recognition and selectivity to SUL and its analogues such as amisulpride and tiapride.Their specific adsorption rates were respectively 68.35%,66.72% and 58.8%.Thus,the MIP could be used in separation and analysis for SUL drugs.