Metabolism Kinetics of Glucose in Anchorage-dependent Cell Cultures

1 INTRODUCTION Glucose is one of the major carbon source and energy source in animal cell cultures1]. The control of glucose at the optimal level is of critical importance for achieving high cell density, product concentration and productivity. This depends largely on the understanding of glucose utilization and regulation in cultured cells. Glucose is utilized either through the pentose phosphate pathway (HMP) to provide nucleotides and reducing power for biosynthesis, or through glyc…