STUDIES OF REACTIVE SENSITIVITY OF CHOLINESTERASES FROM SCIAEMIDAE FISH MUSCLE TO ORGANOPHOSPHATE COMPOUNDES
石首鱼科鱼肌肉胆碱酯酶对有机磷化合物反应灵敏度的研究

The cholinesterases(ChE) show high sensitivity and specificity to inhibition by organophosphate compoundes,but cholinesterases from different biological materials have large difference in the sensitivity.The cholinesterases from Pseudosciaena polyactis,P.crocea,Argyrosomus argentatus,Miichthys,miiuy and Nibea albiflora of the Sciaemidae of Perciformes are very sensitive to Sarin(Isopropyl-methyl-phosphonfluoridate) and VXO-ethyl-s-(2-diisopropylaminoethyl) methylphosphonothiolate],the PI(50) values to Sarin and VX are over 7.0.They will become a effective biological reagent for analysis of organophosphate compoundes and insecticides after further experiments,which may have some guiding signiflcance in screening substances with biological activity.