EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF GABA ON ETHANOL-INDUCED GASTRIC ULCER IN MICE
GABA对乙醇诱导型胃溃疡的影响及其机制分析

Intraeerebroventricularly (i. c. v.) administered GARA (2. 4. 6 umol) significantly accelerated the development of gastric ulcer induced by ethanol (o. p.) in mice in a dose dependent manner, whereas GABA (i. p. 100 umol) could not modify the ethanol-induced ulcer in mice. Atropine (s. c. 0.2mg/kg) exacerbated the ethanol-induced ulcer significantly, while blocking tht: exacerbation of ulcer induced by GABA partly. Regetine (i. m. 2.5 mg/kg) potentiated the ethanol-induced ulcer weakly, and had no effect on the exacerbation of ulcer induced by GABA. These results suggested that exsragenetic GABA exacerbates the ethanol-induced gastric ulcer through central GABA-crgic mechanisms, but not peripherally. Vagus may contribute to gastric protective effect against ulceration. It may be one of main pathway in GABA's action. Sympathetic nerve maybe have relationship with the GABA-ergic mechanisms.