Ultrasound-guided Pingyangmycin injection for huge hepatic hemangioma
超声引导下经皮穿刺平阳霉素注射治疗巨大肝血管瘤

Objective To evaluate the efficacy of Pingyangmycin injection with puncture for large and massive hepatic hemangioma guided by ultrasound.Methods A total of 219 patients suffered from large and massive hepatic hemangioma were diagnosed including a large group of 147 cases（diameter 7-10 cm） and a massive group of 72 cases（diameter ≥10 cm）.Pingyangmycin was injected into the hemangioma from different spots and directions at different times under the guidance of ultrasound.The injection was performed once within a 5-7 days for interval and 6-8 times for a course of treatment.The total amount of Pingyangmycin was not beyond 112 mg.The effectiveness was evaluated after 3 months of injection by ultrasound and the terminal point of evaluation was 2 years after treatment.Results The tumor could not vanish during the treatment.The length of time after treatment is related to the decrease of tumors.After treatment,176（80.37%） cases of tumors vanished or a small nodule with 0.5-1.0 cm was found.Forty-three（19.63%） cases of tumors decreased by 75% with an efficacy rate of 100%.No severe complications of hepatic,renal functional impair and death were reported.There were 3 cases complicated with intraperitoneal hemorrhage.Conclusion The method of puncture with pingyangmycin injection guided by ultrasound for huge hepatic hemangioma are effective and acceptable by patients with less injury.