Multilevel models are overwhelmingly applied to single health outcomes, but when two or more health conditions are closely related, it is important that contextual variation in their joint prevalence (e.g., variations over different geographic settings) is considered. A multinomial multilevel logit regression approach for analysing joint prevalence is proposed here that includes subject level risk factors (e.g., age, race, education) while also taking account of geographic context. Data from a US population health survey (the 2007 Behavioral Risk Factor Surveillance System or BRFSS) are used to illustrate the method, with a six category multinomial outcome defined by diabetic status and weight category (obese, overweight, normal). The influence of geographic context is partly represented by known geographic variables (e.g., county poverty), and partly by a model for latent area influences. In particular, a shared latent variable (common factor) approach is proposed to measure the impact of unobserved area influences on joint weight and diabetes status, with the latent variable being spatially structured to reflect geographic clustering in risk.
References
[1]
Balluz, L; Okoro, C; Mokdad, A. Association between selected unhealthy lifestyle factors, body mass index, and chronic health conditions among individuals 50 years of age or older, by race/ethnicity. Ethn. Dis?2008, 18, 450–457.
[2]
Yach, D; Stuckler, D; Brownell, K. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat. Med?2006, 12, 62–663.
[3]
Mokdad, A; Ford, E; Bowman, B; Nelson, D; Engelgau, M; Vinicor, F; Marks, J. Diabetes trends in the US: 1990–1998. Diabetes Care?2001, 24, 1278–1283.
[4]
Gregg, E; Cheng, Y; Narayan, K; Thompson, T; Williamson, D. The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976–2004. Prev Med?2007, 45, 348–352.
[5]
Paeratakul, S; Lovejoy, J; Ryan, D; Bray, G. The relation of gender, race and socioeconomic status to obesity and obesity comorbidities in a sample of US adults. Int. J. Obes. Relat. Metab. Disord?2002, 26, 1205–1210.
[6]
Cowie, C; Rust, K; Ford, E; Eberhardt, M; Byrd-Holt, D; Li, C; Williams, D; Gregg, E; Bainbridge, K; Saydah, S; Geiss, L. Full accounting of diabetes and pre-diabetes in the US population in 1988–1994 and 2005–2006. Diabetes Care?2009, 32, 287–294.
[7]
Krieger, N; Chen, J; Waterman, P; Rehkopf, D; Subramanian, S. Race/ethnicity, gender, and monitoring socioeconomic gradients in health: a comparison of area-based socioeconomic measures. Amer. J. Public Health?2003, 93, 1655–1671.
[8]
Drewnowski, A; Rehm, C; Solet, D. Disparities in obesity rates: analysis by ZIP code area. Soc. Sci. Med?2007, 65, 2458–2463.
[9]
Lee, R; Cubbin, C; Winkleby, M. Contribution of neighbourhood socioeconomic status and physical activity resources to physical activity among women. J. Epid. Comm. Health?2007, 61, 882–890.
[10]
Cubbin, C; Hadden, W; Winkleby, M. Neighborhood context and cardiovascular disease risk factors: the contribution of material deprivation. Ethn. Dis?2001, 11, 687–700.
[11]
Subramanian, S; Chen, J; Rehkopf, D; Waterman, P; Krieger, N. Racial disparities in context: a multilevel analysis of neighborhood variations in poverty and excess mortality among black populations in Massachusetts. Am. J. Public Health?2005, 95, 260–265.
[12]
Schuurman, N; Peters, P; Oliver, L. Are obesity and physical activity clustered?. A spatial analysis linked to residential density. Obesity?2009.
[13]
Saaddine, J; Narayan, K; Engelgau, M; Aubert, R; Klein, R; Beckles, G. Prevalence of self-rated visual impairment among adults with diabetes. Am. J. Public Health?1999, 89, 1200–1205.
[14]
Jiles, R; Hughes, E; Murphy, W; Flowers, N; McCracken, M; Roberts, H; Ochner, M; Balluz, L; Mokdad, A; Elam-Evans, L; Giles, W. Surveillance for certain health behaviors among states and selected local areas–Behavioral Risk Factor Surveillance System. MMWR Surveill Summ?2005, 54, 1–116.
[15]
Hedeker, D. A mixed-effects multinomial logistic regression model. Stat. Med?2003, 22, 1433–1444.
[16]
Center for Disease Control and Prevention (CDC). Prevalence of diabetes and impaired fasting glucose in adults—United States, 1999–2000. MMWR Surveill Summ?2003, 52, 833–837.
[17]
Freudenberg, N; Ruglis, J. Reframing school dropout as a public health issue. Prev. Chronic Dis?2007, 7, 63.
[18]
Zhang, Q; Wang, Y; Huang, E. Changes in racial/ethnic disparities in the prevalence of Type 2 diabetes by obesity level among US adults. Ethn. Health?2009, 14, 439–457.
[19]
Maty, S; Everson-Rose, S; Haan, M; Raghunathan, T; Kaplan, G. Education, income, occupation, and the 34-year incidence (1965–1999) of Type 2 diabetes in the Alameda County Study. Int. J. Epid?2005, 34, 1282–1283.
[20]
Do, D; Finch, B; Basurto-Davila, R; Bird, C; Escarce, J; Lurie, N. Does place explain racial health disparities? Quantifying the contribution of residential context to the Black/white health gap in the United States. Soc. Sci. Med?2008, 67, 1258–1268.
[21]
Schwartz, F; Ruhil, A; Denham, S; Shubrook, J; Simpson, C; Boyd, S. High self-reported prevalence of diabetes mellitus, heart disease, and stroke in 11 counties of rural Appalachian Ohio. J. Rur. Health?2009, 25, 226–230.
[22]
Mellor, J; Milyo, J. Individual health status and racial minority concentration in US states and counties. Am. J. Public Health?2004, 94, 1043–1048.
[23]
Lopez, R. Neighborhood risk factors for obesity. Obesity?2007, 15, 2111–2119.
[24]
Franz, K; Bailey, S. Geographical variations in heart deaths and diabetes: effect of climate and a possible relationship to magnesium. J. Amer. Coll. Nutr?2004, 23, 521S–524S.
[25]
Pickett, K; Kelly, S; Brunner, E; Lobstein, T; Wilkinson, R. Wider income gaps, wider waistbands? An ecological study of obesity and income inequality. J. Epid. Comm. Health?2005, 59, 670–674.
[26]
Fuller-Thomson, E; Gadalla, T. Income inequality and limitations in activities of daily living: a multilevel analysis of the 2003 American Community Survey. Public Health?2008, 122, 221–228.
[27]
Holtgrave, D; Crosby, R. Is social capital a protective factor against obesity and diabetes? Findings from an exploratory study. Ann. Epidemiol?2006, 16, 406–408.
[28]
Kim, D; Subramanian, S; Gortmaker, S; Kawachi, I. US state- and county-level social capital in relation to obesity and physical inactivity: a multilevel, multivariable analysis. Soc. Sci. Med?2006, 63, 1045–1059.
[29]
Mainous, A; King, D; Garr, D; Pearson, W. Race, rural residence, and control of diabetes and hypertension. Ann. Fam. Med?2004, 2, 563–568.
[30]
Koopman, R; Mainous, A; Geesey, M. Rural residence and Hispanic ethnicity: doubly disadvantaged for diabetes? J. Rur. Health?2005, 22, 63–68.
[31]
Lovasi, G; Neckerman, K; Quinn, J; Weiss, C; Rundle, A. Effect of individual or neighborhood disadvantage on the association between neighborhood walkability and body mass index. Amer. J. Public Health?2009, 99, 279–284.
[32]
Ewing, R; Schmid, T; Killingsworth, R. Relationship between urban sprawl and physical activity, obesity, and morbidity. Amer. J. Health Promot?2003, 18, 47–57.
[33]
Joshu, C; Boehmer, T; Brownson, R; Ewing, R. Personal, neighbourhood and urban factors associated with obesity in the United States. J. Epid. Comm. Health?2008, 62, 202–208.
[34]
Li, F; Harmer, P; Cardinal, B; Bosworth, M; Johnson-Shelton, D; Moore, J; Acock, A; Vongjaturapat, N. Built environment and 1-year change in weight and waist circumference in middle-aged and older adults: Portland Neighborhood Environment and Health Study. Amer. J. Epid?2009, 169, 401–408.
[35]
Ershow, A. Environmental influences on development of type 2 diabetes and obesity: challenges in personalizing prevention and management. J. Diab. Sci. Tech?2009, 3, 727–734.
[36]
Schreinemachers, D. Mortality from ischemic heart disease and diabetes mellitus (type 2) in four U.S. wheat-producing states: a hypothesis-generating study. Environ. Health Perspect?2006, 114, 186–193.
[37]
Sastry, N; Hussey, J. An investigation of race and ethnic disparities in birthweight in Chicago neighborhoods. Demography?2003, 40, 701–725.
[38]
Gregg, E; Cheng, Y; Cadwell, B; Imperatore, G; Williams, D; Flegal, K; Narayan, K; Williamson, D. Secular trends in cardiovascular disease risk factors according to body mass index in US adults. J. Amer. Med. Assoc?2005, 293, 1868–1874.
[39]
Gelfand, A; Smith, A. Sampling based approaches to calculate marginal densities. J. Amer. Statist. Assoc?1990, 85, 398–409.
[40]
Lunn, D; Thomas, A; Best, N; Spiegelhalter, D. WinBUGS – a Bayesian modelling framework: concepts, structure, and extensibility. Stat. Comput?2000, 10, 325–337.
[41]
Spiegelhalter, D; Best, N; Carlin, B; van der Linde, A. Bayesian measures of model complexity and fit. J. Roy. Stat. Soc. B?2002, 64, 583–639.
[42]
Brooks, S; Gelman, A. Alternative methods for monitoring convergence of iterative simulations. J. Comp. Graph. Stat?1998, 7, 434–456.
[43]
Wang, Y; Beydoun, M. The obesity epidemic in the United States–gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epid. Rev?2007, 29, 6–28.
[44]
Papas, M; Alberg, A; Ewing, R; Helzlsouer, K; Gary, T; Klassen, A. The built environment and obesity. Epid. Rev?2007, 29, 129–143.
[45]
Kirschner, A. Poverty in the rural West. Perspect. Poverty Policy Place?2005, 3, 4–6.
[46]
McNeely, M; Boyko, E. Type 2 diabetes prevalence in Asian Americans: results of a national health survey. Diabetes Care?2004, 27, 66–69.
[47]
Broussard, B; Johnson, A; Himes, J; Story, M; Fichtner, R; Hauck, F; Bachman-Carter, K; Hayes, J; Frohlich, K; Gray, N. Prevalence of obesity in American Indians and Alaska Natives. Amer. J. Clin. Nutr?1991, 53, 1535S–1542S.
[48]
Geiss, L; Pan, L; Cadwell, B; Gregg, E; Benjamin, S; Engelgau, M. Changes in incidence of diabetes in U.S. adults, 1997–2003. Amer. J. Prev. Med?2006, 30, 371–377.
[49]
Duncan, C; Jones, K; Moon, G. Context, composition and heterogeneity: using multilevel models in health research. Soc. Sci. Med?1998, 46, 97–117.
[50]
Sacker, A; Wiggins, R; Bartley, M. Time and place: putting individual health into context. A multilevel analysis of the British household panel survey, 1991–2001. Health Place?2006, 12, 279–290.
[51]
Gamerman, D; Moreira, A; Rue, H. Space-varying regression models specifications and simulation. Comput. Statist. Data Analysis?2003, 42, 513–533.
[52]
Fahrmeir, L; Lang, S. Bayesian inference for generalized additive mixed models based on Markov random field priors. J. Roy. Stat. Soc. C?2001, 50, 201–220.
[53]
Besag, J; York, J; Mollie, A. Bayesian image restoration, with two applications in spatial statistics. Ann. Inst. Statist. Math?1991, 43, 1–59.