The Present and the Future of Biopharmaceuticals(2):Trends and Prospects
生物制药的现状和未来（二）：发展趋势与希望

Both genomics and proteomics are contributing to understanding and determining more targets which involved in the development of human disease, and will enable us to develop more precise medicine to treat and prevent more diseases. This means there will be more opportunities for biopharmaceutical breakthroughs, eventually, more and better biomedicines will be approved. There are several trends in development for biopharmaceuticals: (1) the products expressed by mammalian cell will dominate the biopharmaceutical industry for a long time. (2)Therapeutic antibodies represent the second wave of innovation created by the biopharmaceutical industry. (3)More and more macromolecular and functional proteins with complex structure will be developed into therapeutic medicines, especially for treatment of hereditary diseases. (4) Chemical modifies, especially PEGylation of approved biomedicines to improve efficacy is one of the trends in development of new biotech drugs. (5) Site-directed mutagenesis of some biotech drugs to get second generation biomedicines, such as mutants of EPO, insulin and t-PA. (6)Tissue engineering, cell therapy and gene therapy are full of opportunities and challenges.