Endocytosis of Ca alginate nanocapsules by dendritic cells and function induction
树突状细胞对海藻酸钙纳米胶囊的吞噬作用与功能诱导

The endocytosis/phagocytosis of calcium alginate nanocapsules by peripheral blood derived dendritic cells was confirmed with the use of Quantum dots labeling. Results further demonstrated these nanoparticles could cause the upregulation of HLA-DR expression to induce the maturation of dendritic cells in vitro. Dendritic cells stimulated by nanocapsules covalently loaded with BSA were shown to stimulate the proliferation of self T cells with blank capsules and free BSA as controls, suggesting their potential applications in cancer cell therapy as a new antigen delivery vehicle with a strong adjuvant effect.