NUMERICAL SIMULATION OF ARTERIAL REMODELING IN RESPONSE TO ACUTE HYPERTENSION
急性高血压引起血管重建的数值模拟

Studies on hypertension-induced vascular remodeling not only help understand the specific self-adaptive features of living materials, but also are of great instructive significance for the pathological research and effective prevention and treatment of hypertension. Thus, study on vascular remodeling caused by hypertension has been one of current research hotspots. In this study, remodeling rate equations were established to simulate the evolution of the arterial remodeling behavior in response to acute hypertension. The temporal variations of vascular geometric configuration and mean circumferential stress were calculated under acute hypertension condition. In order to embody the temporal and spatial nonuniformity of the arterial wall remodeling, growing factors were introduced in this paper so that the remodeling process of the zero-stress state of the artery can be controlled effectively. The numerical results, obtained respectively from the abdominal aortas of six rats, showed that the arterial wall remodeling of these different rats appeared the same remodeling trend and feature, which demonstrated that the method in this paper for simulating arterial wall remodeling in response to acute hypertension has catholicity in some degree. Due to the introduction of the growing factors in the analytical model, the simulated remodeling process was in reasonable agreement with the basic physiological and pathological features (especially during several days after the loa,d of high blood pressure) of arterial remodeling in response to acute hypertension revealed by Liu and Fung.