Palladium Catalyzed Csp-Csp3 Bond Formation Reaction Studied by 13C NMR
钯催化Csp-Csp3偶联反应的13C NMR定量研究

NOE-enhanced 13C NMR spectroscopy was used to study palladium-catalyzed Csp-Csp3 bond formation reaction in real-time. The NOE factors for different peaks of the same substance were found to be almost the same throughout the course of reaction. The changes of the concentrations of the reactants and products were measured quantitatively during the reaction. The results of the NMR experiments provided direct evidence for the reaction mechanism proposed by Lei et al (J Am Chem Soc, 2006, 128: 15 048-15 049).