Structure Elucidation of Polyene Macrolide Antibiotic Lucensomycin
多烯大环内酯抗生素——鲁丝霉素的结构解析

Polyene macrolide antibiotics are cyclic compounds composed of 25 to 37 carbons, with conjugated polyene fragment and substituted by hydroxyl and glycosidation of aminosaccharide. They have the characteristics of light instability, wide antifungal spectrum, high toxicity by intravenous injection and low toxicity by oral administration. In this study, lucensomycin, an antifungal active substance produced from actinomycetes-1356, was characterized by UV, IR, MS, and NMR spectroscopy. It was found that the 13C NMR chemical shifts of some of the olefinic carbons of this compound were mistakenly assigned in the literature. The regularity for NMR data of polyene macrolide was also summarized in the paper.