Structure Elucidation of Polyene Macrolide Antibiotic Lucensomycin by 2D NMR
应用2D NMR技术对多烯大环内酯抗生素——鲁丝霉素进行结构解析

Polyene macrolide antibiotic is composed of 25 to 37 carbons with conjugated polyene fragment, substituted by hydroxyl and glycosidation of aminopolysaccharide. It has the characteristics of light unstability, wide antifungal spectrum, low toxicity by intravenous injection, high toxicity by oral administration. In this paper, it was reported that the idntification and detailed assignment of Lucensomycin, antifungal active substance produced from actinomycetes-1356, by means of UV, IR, MS, 1D and 2D NMR technology. Furthermore, the deficiency of 13C NMR data for olefinic carbons reported in literature was also corrected and the regularity for NMR data of polyene macrolide was summarized.