AUTOMATIC PHASE CORRECTION FOR NMR SPECTRA-CONNECTING LINE OF EQUALLY SPACED POINTS(CLESP)
核磁共振谱图自动相位校正新方法——等密度点连线法

A novel automatic phase correction method, CLESP, for NMR spectra based on DISPA circle is described in this paper. The phase angles of peaks are determined from the slope of the line connecting two peak points with equal data point density on each side of the peak on the complex plane. The calculated phase angles of the peaks are then used to extract the zero-order and first-order phase correction for the full spectrum by linear regression. In addition to the advantages of being non-iterative, fast, accurate, straightforward, easy to implement, and applicable to partial peaks, CLESP is robust with respect to noise, baseline distortion, peak overlaps, and poor digitization of NMR signals. CLESP algorithm has been successfully implemented in ECNMR , a home-made NMR data-processing software.