Synthesis and NMR Characterization of Diethyl Puerarin-7-yl Phosphate
葛根素-7-磷酸二乙酯的NMR研究

Puerarin,an isoflavone compound,is the bioactive component of traditional Chinese medicine puerarin lobate(wild).A novel diethyl puerarin-7-yl phosphate was synthesized by the Atherton-Todd reaction with high productive yield.It was found that the compound synthesized has two sets of NMR signals at room temperature,suggesting the existence of two conformational isomers in solution.The1H chemical shifts of the compound were assigned using two-dimensional NMR techniques,including1H-detected heteronuclear multiple-quantum coherence and1H-detected multiple-bond heteronuclear multiple-quantum coherence.