Protein folding and the formation of inclusion bodies
蛋白质的折叠调控与包涵体的形成

Newly synthesized polypeptide chains must be folded and assembled into unique three-dimensional structures in order to become functionally active. In the folding process,many misfolded proteins maybe produced and thus accumulate as aggregates. Quality control over protein structure and function depends on the presence of molecular chaperones and proteases, which prevent aggregation. In this article, the mechanism and characteristics of aggregation and inclusion bodies are summarized. Furthermore, the roles of chaperones and proteases in inclusion body formation are discussed.