Development and application of combined multivalent egg-yolk antibodies in passive protection of piglet diarrhea caused by enterotoxicgenic E.coli
仔猪大肠杆菌病复合多价卵黄抗体的研制与应用

A mixture of cultures of K88-,K99-,987P- and F_41- piliate enterotoxigenic E. coliwas used to immunize hens to produce eggs containing antibodies against enterotoxigenic E.coli,from which the antibodies were extracted and purified.The purified antibodies were mixed with the Chinese traditional medicine and protectives proportionally to make up the combined multivalent chicken egg-yolk antibodies,and then produce the powder by spray drying process.In the treatment trial of infected piglets,the cure rate using the combined multivalent chicken egg-yolk antibody dry powder is higher than that of Gentamycin.In the prevention trial,the oral administration of the combined multivalent chicken egg-yolk antibodies has an higher prevention effect significantly than that of vaccine against enterotoxigenic Escherichia coli.It is concluded that the combined multivalent chicken egg-yolk antibody powder is a new,safe and effective preparation in prevention and treatment of piglet diarrhea caused by enterotoxigenic E.coli.