Biological effects of 4- chloro-2,6-dipicolinatodioxovanadium ( Ⅳ ) in streptozotocin-induced diabetic rats
4-氯-2,6-双吡啶双氧钒化合物降低1型糖尿病大鼠血糖的生物学作用

The insulin-mimic effect of vanadium compounds has been widely reported in both type 1 and 2 diabetes animal models. Recently, various organic vanadium compounds have been synthesized to lower the side effect of inorganic vanadium and improve its poor absorption efficiency. In the present study, we evaluated the biological effects of V_4dipic-Cl in streptozotocin (STZ)-induced diabetic rats. V_4dipic-Cl was orally administrated to diabetic rats for eight days at the dose of 0.5mg/mL through drinking water. The blood glucose level, serum alkaline phosphorase (ALP), aspartate amino transferase (AST) and blood urea nitrogen (BUN) were determined. In addition, an oral glucose tolerance test was carried out. The results showed that blood glucose, serum ALP, AST and BUN were significantly increased in STZ induced-diabetic rats. The level of glucose tolerance in diabetic rats was lower than that in the controls. At the end of the experiment, blood glucose and serum ALP in V_4dipic-Cl-treated diabetic rats were significantly decreased. Meanwhile, oral glucose tolerance of diabetic rats was improved as compared to the H_2dipic-Cl-treated diabetic rats. In conclusion, it was found that V_4dipic-Cl could decrease blood glucose level and restore the hyperglycemia-induced hepatic dysfunction in STZ-induced diabetic rats.