Sirt1: A Novel Adipocyte and Myocyte Regulatory Factor
Sirt1: 一种新的脂肪细胞和肌细胞调控因子

Sirt1(Sirtuin type 1), a member of the conserved sirtuin family, is a NAD+-dependent histone deacetylase. It is intimately related to cell proliferation, differentiation, apoptosis, and metabolism. Its role in senescence and metabolism has recently come to light. Sirti promotes fat mobilization in white adipocytes by repressing PPARv and inhibits myoblast differentiation by down-regulating muscle gene expression. Therefore, Sirti is not only an important longevity factor, but also may play a key modulatory role in animal fat deposition and muscle development.