Meta-Analysis of the Association of the LRP C766T Polymorphism with the Risk of Alzheimer''''s Disease
低密度脂蛋白受体相关蛋白基因C766T多态性与阿尔茨海默氏病发病风险的Meta-分析

A C-to-T polymorphism in exon 3 of the low density lipoprotein receptor-related protein 1(LRP-1) gene has been implicated as a risk factor for Alzheimer's disease(AD).The authors performed a meta-analysis to investigate the association between the C766T polymorphism in the LRP-1 gene and the risk for AD.Nineteen references were retrieved through Medline,Cochran Library and CBM search from 1997 to 2004.Similar search strategies were applied to each of these databases.Studies which were eligible for the meta-analysis should meet the following inclusion criteria: presentation of original data and a cross-sectional design,AD as the outcome of interest,an odds ratio(or enough information to calculate it) reported to quantify the association between the frequencies of genotypes and/or alleles of LRP-1 gene C766T polymorphism and the risk for AD.All analyses were performed with Review Manager 4.2.A total of 3 764 AD patients and 3 647 control subjects were analyzed according to the random effect model because some between-study heterogeneity was found(P<0.01).The combined data statistics revealed that there was no statistical difference(test for overall effect: Z=1.74,P=0.08,OR=1.17,95% CI: 0.98~1.39;Z=1.31, P=0.19,OR=1.11,95% CI:0.95~1.31) in the frequencies of allele and genotype between the AD patients and the controls.The meta-analysis showed that the LRP-1 polymorphism was not a major risk factor for AD,although a small effect of the polymorphism for AD risk could not be excluded.