Comparing the Distribution of Genetic Polymorphism of MTHFR Thermolabile between Mongolian Population and Hans of China
中国汉蒙两族人群MTHFR基因热敏感性多态性分布的比较 Comparing the Distribution of Genetic Polymorphism of MTHFR Thermolabile between Mongolian Population and Hans of China

Keywords: Mongolian population and Hans,polymerase chain reaction(PCR),MTHFR,genetic polymorphism
热敏感性,多态性,汉族,蒙族,MTHFR基因,PCR

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Abstract:

为比较中国蒙汉两族人群ＭＴＨＦＲ基因第６７７位核苷酸多态性的分布情况，获得该位点多态性的群体遗传学数据，本研究应用ＰＣＲ扩增技术，其扩增产物用限制性核酸内切酶ＨｉｎｆⅠ消化后进行非变性聚丙烯酰胺凝胶电泳，分析蒙汉族人群中ＭＴＨＦＲ基因第６７７位核苷酸基因型（野生型、杂合型和突变纯合型）的分布频率，结果表明，蒙族人群基因型构成以野生型为主，占４５．６％，突变杂合型占３９．２％，突变纯合型仅占１５．２

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