多巴胺D4受体基因与注意缺损多动障碍 The Association Between Attention-deficit Hyperactivity Disorder and Dopamine Receptor D4 Gene

为探讨注意缺损多动障碍(ADHD)与多巴胺D4受体基因(dopamineD4receptorgene,DRD4)间的关系,采用Amp-FLP的方法检测了上海地区汉族人群中68例ADHD患者及其父母DRD4的多态性,数据采用基于单体型的单体型相对风险(HHRR)及传递不平衡检验(TDT)进行遗传关联分析.结果表明HHRR分析和复等位基因的TDT检验,均未显示出与ADHD的遗传关联性(P＞0.05).提示上海地区人群中DRD4基因与ADHD无显著性关联。 Abstract:The present study was designed to investigate the association between attention-deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene (DRD4).Amp-FLP was used to test the polymorphisms of DRD4 in 68 ADHD children and their parents from Shanghai.The haplotype-based haplotype relative risk (HHRR) and transmission disequilibrium test (TDT) methods were used to analyze the association between DRD4 and ADHD.In our samples we found no significant association between DRD4 and ADHD (P>0.05).Our results do not support that ADHD is associated with DRD4 in population in Shanghai.