Advances in Allelic Polymorphism at Class Ⅱ of the Pig MHC(SLA)
猪白细胞Ⅱ类抗原基因多态性研究进展 Advances in Allelic Polymorphism at Class Ⅱ of the Pig MHC(SLA)

This article gave a detailed introduction about regional map,molecular structure,genotyping and polymorphism of SLA class II genes. The pig major histocompatibility complex (MHC) class II antigens have been known to exhibit a different degree of allelic polymorphism. The locus-specific oligonucleotide primers and RFLP analysis provide a simple and rapid method for genotyping expressed SLA class II from genomic DNA. SLA class II polymorphism was related to the antigenic peptide binding sites. Detailed analysis of sequences showed that there were 4 GC-rich sequences in exon 2 of SLA-DQB and SLA-DRB1 genes.