Mutational Analysis of the Promotor Region of SRY Gene in 46, XY Females
46,XY女性患者SRY基因启动子区域的突变分析 Mutational Analysis of the Promotor Region of SRY Gene in 46,XY Females

Using restrietion endonuelease digestion and PCR- SSCP with silver staining, we analyzed the promotor region of SRY gene in seven 46, XY females. The results showed no abnormality, thus ruling out the mutations in the promotor region of the SRY gene as a possible cause of sex reversal in these XY females. In view with the absenee of the mutations in the HMG regions of the SRY genes of several patients,it is suggested that SRY gene is not the only gene responsible for testieular development but is one of many hicrarchical genes involved in a genetic easeadc for sexual differentiation.