Study on G/A Polymorphisms in Intron 27 of Fibrillin-1 Gene in Chinese Han Population
中国汉族人群原纤维蛋白-1基因(FBN1)第27内含子G/A多态性 Study on G/A Polymorphisms in Intron27 of Fibrillin-1 Gene in Chinese Han Population

The G / A polymorphisms in intron 27 of fibrillin-1 gene in 101 Chinese Hans who were studying and working in University of Tsukuba, Japan were analyzed with PCR-ASO method. The frequencies of A and G alleles, were 0.5396 and 0.4604 respectively. In a population sample reported by Tynan the frequency of A allele was 0.1675 while that of G alle1e was 0. 8325. The distribution of G / A polymorphism was significantly different betwecn the two population sample (P<0. 01), suggesting different genetic backgrounds.