The Effect of Cholecystokinin Octapeptide on Lipopolysaccharide-induced Sickness Behavior and Peripheral Cytokine Secretion
胆囊收缩素对脂多糖诱发的病态行为及外周细胞因子的影响

Cytokines have been considered to be involved in the pathology of sickness behavior,but the role of peripheral cytokines in the pathology of sickness behavior is still elusive.Cholecystokinin octapeptide(CCK-8) has been proved to inhibit the lipopolysaccharide(LPS)-induced secretion of peripheral proinflammatory cytokines in rats.Aim:To investigate the role of peripheral cytokines in the pathology of sickness behavior.Methods:The experiment included two parts.In Experiment 1,forty-six rats were randomly div...