Investigation of HA/chitosan Composite Coatings Prepared by Sol-Gel on Alkali Treated Titanium Surfaces
钛表面制备羟基磷灰石/壳聚糖复合涂层研究

Hydroxyapatite/chitosan (HA/CS) composite coatings were prepared on titanium surfaces by hydro-thermal synthesis and Sol-Gel method. The composition, structure, morphology and biocompatibility of composite coatings were characterized. Ti surfaces are convertedinto super-hydrophilic surfaces by alkali treatment, XRD analysis reveals that the coatings are mainly composed of HA and CS and their compositions are determined by TG analysis. SEM observation shows that the coatings with different HA content have different morphologies. Osteoblasts are cultured on the coatings to evaluate their biocompatibility. Alamar Blue assay indicates that cells on the composite coatings has larger proliferation rate than those on pure titanium. Also the ALP activity of the cells on the composite coatings is higher than that on the pure titanium samples. The results demonstrate that as-prepared HA/CS composite coatings have good biocompatibility.