Background The beneficial effects of brain training games are expected to transfer to other cognitive functions, but these beneficial effects are poorly understood. Here we investigate the impact of the brain training game (Brain Age) on cognitive functions in the elderly. Methods and Results Thirty-two elderly volunteers were recruited through an advertisement in the local newspaper and randomly assigned to either of two game groups (Brain Age, Tetris). This study was completed by 14 of the 16 members in the Brain Age group and 14 of the 16 members in the Tetris group. To maximize the benefit of the interventions, all participants were non-gamers who reported playing less than one hour of video games per week over the past 2 years. Participants in both the Brain Age and the Tetris groups played their game for about 15 minutes per day, at least 5 days per week, for 4 weeks. Each group played for a total of about 20 days. Measures of the cognitive functions were conducted before and after training. Measures of the cognitive functions fell into four categories (global cognitive status, executive functions, attention, and processing speed). Results showed that the effects of the brain training game were transferred to executive functions and to processing speed. However, the brain training game showed no transfer effect on any global cognitive status nor attention. Conclusions Our results showed that playing Brain Age for 4 weeks could lead to improve cognitive functions (executive functions and processing speed) in the elderly. This result indicated that there is a possibility which the elderly could improve executive functions and processing speed in short term training. The results need replication in large samples. Long-term effects and relevance for every-day functioning remain uncertain as yet. Trial Registration UMIN Clinical Trial Registry 000002825
References
[1]
Hedden T, Gabrieli JDE (2004) Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 5: 87–96.
[2]
Nilsson L-G (2003) Memory function in normal aging. Acta Neurologica Scandinavica 107: 7–13.
[3]
Salthouse TA (2003) Memory aging from 18 to 80. Alzheimer Dis Assoc Disord 17: 162–167.
[4]
Yakhno NN, Zakharov VV, Lokshina AB (2007) Impairment of memory and attention in the elderly. Neurosci Behav Physiol 37: 203–208.
[5]
Coppin AK, Shumway-Cook A, Saczynski JS, Patel KV, Ble A, et al. (2006) Association of executive function and performance of dual-task physical tests among older adults: analyses from the InChianti study. Age Ageing 35: 619–624.
[6]
Royall DR, Palmer R, Chiodo LK, Polk MJ (2004) Declining Executive Control in Normal Aging Predicts Change in Functional Status: The Freedom House Study. J Am Geriatr Soc 52: 346–352.
[7]
Salthouse TA (1996) The processing-speed theory of adult age differences in cognition. Psychological Review 103: 403–428.
[8]
Lee Y, Kim JH, Lee KJ, Han G, Kim JL (2005) Association of cognitive status with functional limitation and disability in older adults. Aging Clin Exp Res 17: 20–28.
[9]
Cahn-Weiner DA, Malloy PF, Boyle PA, Marran M, Salloway S (2000) Prediction of functional status from neuropsychological tests in community-dwelling elderly individuals. Clin Neuropsychol 14: 187–195.
[10]
Owsley C, McGwin G (2004) Association between visual attention and mobility in older adults. J Am Geriatr Soc 52: 1901–1906.
[11]
Kempermann G, Gast D, Gage FH (2002) Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol 52: 135–143.
[12]
Jones S, Nyberg L, Sandblom J, Stigsdotter Neely A, Ingvar M, et al. (2006) Cognitive and neural plasticity in aging: general and task-specific limitations. Neurosci Biobehav Rev 30: 864–871.
[13]
Acevedo A, Loewenstein DA (2007) Nonpharmacological cognitive interventions in aging and dementia. J Geriatr Psychiatry Neurol 20: 239–249.
[14]
Smith GE, Housen P, Yaffe K, Ruff R, Kennison RF, et al. (2009) A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc 57: 594–603.
[15]
Mahncke HW, Connor BB, Appelman J, Ahsanuddin ON, Hardy JL, et al. (2006) Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc Natl Acad Sci U S A 103: 12523–12528.
[16]
Ball K, Berch DB, Helmers KF, Jobe JB, Leveck MD, et al. (2002) Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA 288: 2271–2281.
[17]
Edwards JD, Wadley VG, Vance DE, Wood K, Roenker DL, et al. (2005) The impact of speed of processing training on cognitive and everyday performance. Aging Ment Health 9: 262–271.
[18]
Ball K, Edwards JD, Ross LA (2007) The impact of speed of processing training on cognitive and everyday functions. J Gerontol B Psychol Sci Soc Sci 62: 19–31.
[19]
Uchida S, Kawashima R (2008) Reading and solving arithmetic problems improves cognitive functions of normal aged people: a randomized controlled study. Age (Dordr) 30: 21–29.
[20]
Mozolic JL, Long AB, Morgan AR, Rawley-Payne M, Laurienti PJ (2011) A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults. Neurobiol Aging 32: 655–668.
[21]
Lustig C, Shah P, Seidler R, Reuter-Lorenz P (2009) Aging, training, and the brain: a review and future directions. Neuropsychol Rev 19: 504–522.
[22]
Green CS, Bavelier D (2008) Exercising your brain: a review of human brain plasticity and training-induced learning. Psychol Aging 23: 692–701.
[23]
Basak C, Boot WR, Voss MW, Kramer AF (2008) Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychol Aging 23: 765–777.
[24]
Goldstein J, Cajko L, Oosterbroek M, Michielsen M, Houten O Van, et al. (1997) Video game and the elderly. Social Behavior and Personality: an international journal 25: 345–352.
[25]
Clark JE, Lanphear AK, Riddick CC (1987) The effects of videogame playing on the response selection processing of elderly adults. J Gerontol 42: 82–85.
[26]
Dustman RE, Emmerson RY, Steinhaus LA, Shearer DE, Dustman TJ (1992) The effects of videogame playing on neuropsychological performance of elderly individuals. J Gerontol 47: 168–171.
[27]
Owen AM, Hampshire A, Grahn Ja, Stenton R, Dajani S, et al. (2010) Putting brain training to the test. Nature 465: 775–778.
[28]
Jaeggi SM, Buschkuehl M, Jonides J, Shah P (2011) Short- and long-term benefits of cognitive training. Proc Natl Acad Sci U S A 108: 10081–10086.
[29]
Logie RH, Sala SD (2010) Brain training in schools, where is the evidence? British Journal of Educational Technology 41: E127–E128.
[30]
Fuyuno I (2007) Brain craze. Nature 447: 18–20.
[31]
Green CS, Bavelier D (2003) Action video game modifies visual selective attention. Nature 423: 534–537.
[32]
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198.
[33]
Dubois B, Slachevsky A, Litvan I, Pillon B (2000) The FAB: a Frontal Assessment Battery at bedside. Neurology 55: 1621–1626.
[34]
Reitan RM (1958) Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills 8: 271–276.
[35]
Hatta T, Ito Y, Yoshizaki K (2006) D-CAT manual (Screening test for attention). Osaka: Union Press.
[36]
Wechsler DA (1997) Wechsler Adult Intelligence Scale Third edition. San Antonio, , TX: The Psychological Corporation.
[37]
Boot WR, Kramer AF, Simons DJ, Fabiani M, Gratton G (2008) The effects of video game playing on attention, memory, and executive control. Acta Psychol (Amst) 129: 387–398.
[38]
Maki N, Ikeda M, Hokoishi K, Nebu A, Komori K, et al. (2000) The validity of the MMSE and SMQ as screening tests for dementia in the elderly general population– a study of one rural community in Japan. Dement Geriatr Cogn Disord 11: 193–196.
[39]
Dodge HH, Meguro K, Ishii H, Yamaguchi S, Saxton JA, et al. (2009) Cross-cultural comparisons of the Mini-mental State Examination between Japanese and U.S. cohorts. Int Psychogeriatr 21: 113–122.
[40]
Kawashima R, Taira M, Okita K, Inoue K, Tajima N, et al. (2004) A functional MRI study of simple arithmetic—a comparison between children and adults. Cognitive Brain Research 18: 227–233.
[41]
Miura N, Iwata K, Watanabe J, Sugiura M, Akitsuki Y, et al. (2003) Cortical activation during reading aloud of long sentences: fMRI study. Neuroreport 14: 1563–1566.
[42]
Cohen J (1988) Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, , NJ: Lawrence Earlbaum Associates.
[43]
West RL (1996) An application of prefrontal cortex function theory to cognitive aging. Psychol Bull 120: 272–292.
[44]
Vaughan L, Giovanello K (2010) Executive function in daily life: Age-related influences of executive processes on instrumental activities of daily living. Psychol Aging 25: 343–355.
[45]
Jonides J (2004) How does practice makes perfect? Nat Neurosci 7: 10–11.
[46]
Dahlin E, Neely AS, Larsson A, B？ckman L, Nyberg L (2008) Transfer of learning after updating training mediated by the striatum. Science 320: 1510–1512.
[47]
Persson J, Reuter-Lorenz PA (2008) Gaining control: training executive function and far transfer of the ability to resolve interference. Psychological Science 19: 881–888.
[48]
Kennedy KM, Raz N (2009) Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia 47: 916–927.
[49]
Stuss DT, Robertson IH, Craik FIM, Levine B, Alexander MP, et al. (2007) Cognitive rehabilitation in the elderly: a randomized trial to evaluate a new protocol. J Int Neuropsychol Soc 13: 120–131.
[50]
Barnett SM, Ceci SJ (2002) When and where do we apply what we learn? A taxonomy for far transfer. Psychol Bull 128: 612–637.
[51]
Edwards JD, Wadley VG, Myers R eneeS, Roenker DL, Cissell GM, et al. (n.d.) Transfer of a speed of processing intervention to near and far cognitive functions. Gerontology 48: 329–340.
[52]
Jonker C, Geerlings MI, Schmand B (2000) Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry 15: 983–991.
