Study on bursting of pancreatic β cells in codimension-2 bifurcation regions
双参数分岔平面内胰腺β细胞的簇放电分析

Electrical activities of insulin secretion in pancreatic islets are characterized by bursts of action potentials. With a simple but representative Vries-Sherman model, we determine the regions of different types of bursting in two-parameter plane through the two-parameter bifurcation analysis of the fast subsystem. Moreover, fast/slow analysis is used to reveal topological types of bursting patterns for different values of the parameter Vm and transition mechanisms between them.