| [1] | Munoz-Descalzo S, Terol J, Paricio N (2005) Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling. Dev Biol 287: 168–179.
|
| [2] | Beckstead RB, Lam G, Thummel CS (2005) The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol 6: R99.
|
| [3] | Zhao T, Gu T, Rice HC, McAdams KL, Roark KM, et al. (2008) A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. Genetics 178: 883–901.
|
| [4] | Blanco E, Ruiz-Romero M, Beltran S, Bosch M, Punset A, et al. (2010) Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. BMC Dev Biol 10: 94.
|
| [5] | Kadener S, Stoleru D, McDonald M, Nawathean P, Rosbash M (2007) Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev 21: 1675–1686.
|
| [6] | Kraut R, Menon K, Zinn K (2001) A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. Curr Biol 11: 417–430.
|
| [7] | Mindorff EN, O'Keefe DD, Labbe A, Yang JP, Ou Y, et al. (2007) A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting. Genetics 176: 2247–2263.
|
| [8] | Yatsu J, Hayashi M, Mukai M, Arita K, Shigenobu S, et al. (2008) Maternal RNAs encoding transcription factors for germline-specific gene expression in Drosophila embryos. Int J Dev Biol 52: 913–923.
|
| [9] | Bulow MH, Aebersold R, Pankratz MJ, Junger MA (2010) The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin. PLoS One 5: e15171.
|
| [10] | Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM (2006) Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol 16: 958–970.
|
| [11] | Gorski SM, Chittaranjan S, Pleasance ED, Freeman JD, Anderson CL, et al. (2003) A SAGE approach to discovery of genes involved in autophagic cell death. Curr Biol 13: 358–363.
|
| [12] | Rodriguez I (2011) Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation. PLoS One 6: e18418.
|
| [13] | Belacortu Y, Weiss R, Kadener S, Paricio N (2011) Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development. Gene Expr Patterns 11: 190–201.
|
| [14] | Munoz-Descalzo S, Belacortu Y, Paricio N (2007) Identification and analysis of cabut orthologs in invertebrates and vertebrates. Dev Genes Evol 217: 289–298.
|
| [15] | Seetharam A, Bai Y, Stuart GW (2010) A survey of well conserved families of C2H2 zinc-finger genes in Daphnia. BMC Genomics 11: 276.
|
| [16] | Suske G, Bruford E, Philipsen S (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85: 551–556.
|
| [17] | Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R (1998) Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. J Biol Chem 273: 25929–25936.
|
| [18] | Kaczynski J, Cook T, Urrutia R (2003) Sp1- and Kruppel-like transcription factors. Genome Biol 4: 206.
|
| [19] | Wang Z, Peters B, Klussmann S, Bender H, Herb A, et al. (2004) Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins. Gene 325: 25–34.
|
| [20] | Spittau B, Krieglstein K (2011) Klf10 and Klf11 as mediators of TGF-beta superfamily signaling. Cell Tissue Res. DOI 10.1007/s00441-011-1186-6.
|
| [21] | Subramaniam M, Harris SA, Oursler MJ, Rasmussen K, Riggs BL, et al. (1995) Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res 23: 4907–4912.
|
| [22] | Chen Z, Lei T, Chen X, Zhang J, Yu A, et al. (2010) Porcine KLF gene family: Structure, mapping, and phylogenetic analysis. Genomics 95: 111–119.
|
| [23] | Cook T, Urrutia R (2000) TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth. Am J Physiol Gastrointest Liver Physiol 278: G513–521.
|
| [24] | Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, et al. (2005) TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol 25: 1191–1199.
|
| [25] | Bender H, Wang Z, Schuster N, Krieglstein K (2004) TIEG1 facilitates transforming growth factor-beta-mediated apoptosis in the oligodendroglial cell line OLI-neu. J Neurosci Res 75: 344–352.
|
| [26] | Chalaux E, Lopez-Rovira T, Rosa JL, Pons G, Boxer LM, et al. (1999) A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cells. FEBS Lett 457: 478–482.
|
| [27] | Gohla G, Krieglstein K, Spittau B (2008) Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7. J Cell Biochem 104: 850–861.
|
| [28] | Hirota T, Kon N, Itagaki T, Hoshina N, Okano T, et al. (2010) Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. Genes Cells 15: 111–121.
|
| [29] | Subramaniam M, Hawse JR, Johnsen SA, Spelsberg TC (2007) Role of TIEG1 in biological processes and disease states. J Cell Biochem 102: 539–548.
|
| [30] | Tachibana I, Imoto M, Adjei PN, Gores GJ, Subramaniam M, et al. (1997) Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J Clin Invest 99: 2365–2374.
|
| [31] | Cook T, Gebelein B, Belal M, Mesa K, Urrutia R (1999) Three conserved transcriptional repressor domains are a defining feature of the TIEG subfamily of Sp1-like zinc finger proteins. J Biol Chem 274: 29500–29504.
|
| [32] | Spittau B, Wang Z, Boinska D, Krieglstein K (2007) Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain. J Cell Biochem 101: 712–722.
|
| [33] | Fernandez-Zapico ME, van Velkinburgh JC, Gutierrez-Aguilar R, Neve B, Froguel P, et al. (2009) MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. J Biol Chem 284: 36482–36490.
|
| [34] | Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, et al. (2005) Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A 102: 4807–4812.
|
| [35] | Noti JD, Johnson AK, Dillon JD (2004) The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter. J Biol Chem 279: 26948–26958.
|
| [36] | Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, et al. (2001) A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. Mol Cell Biol 21: 5041–5049.
|
| [37] | Kim J, Shin S, Subramaniam M, Bruinsma E, Kim TD, et al. (2010) Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem Biophys Res Commun 401: 412–416.
|
| [38] | Pandya K, Townes TM (2002) Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1. J Biol Chem 277: 16304–16312.
|
| [39] | Quadrini KJ, Bieker JJ (2002) Kruppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid Kruppel-like factor. J Biol Chem 277: 32243–32252.
|
| [40] | Boulikas T (1993) Nuclear localization signals (NLS). Crit Rev Eukaryot Gene Expr 3: 193–227.
|
| [41] | Cokol M, Nair R, Rost B (2000) Finding nuclear localization signals. EMBO Rep 1: 411–415.
|
| [42] | Poon IK, Jans DA (2005) Regulation of nuclear transport: central role in development and transformation? Traffic 6: 173–186.
|
| [43] | Fernandez-Costa JM, Artero R (2010) A conserved motif controls nuclear localization of Drosophila Muscleblind. Mol Cells 30: 65–70.
|
| [44] | Mosca TJ, Schwarz TL (2010) Drosophila Importin-alpha2 is involved in synapse, axon and muscle development. PLoS One 5: e15223.
|
| [45] | Wong LC, Schedl P (2006) Dissection of Drosophila ovaries. J Vis Exp 52.
|
| [46] | Munoz-Soriano V, Belacortu Y, Durupt FC, Munoz-Descalzo S, Paricio N (2011) Mtl interacts with members of Egfr signaling and cell adhesion genes in the Drosophila eye. Fly (Austin) 5: 88–101.
|
| [47] | Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673–4680.
|
| [48] | Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401–415.
|
| [49] | Brown JL, Grau DJ, DeVido SK, Kassis JA (2005) An Sp1/KLF binding site is important for the activity of a Polycomb group response element from the Drosophila engrailed gene. Nucleic Acids Res 33: 5181–5189.
|
| [50] | Lowrey PL, Takahashi JS (2004) Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet 5: 407–441.
|
| [51] | Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418: 935–941.
|
| [52] | Wager-Smith K, Kay SA (2000) Circadian rhythm genetics: from flies to mice to humans. Nat Genet 26: 23–27.
|
| [53] | Pang YP, Kumar GA, Zhang JS, Urrutia R (2003) Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A. FEBS Lett 31: 108–12.
|
| [54] | Schwede T, Kopp J, Guex N, Peitsch MC (2003) SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res 31: 3381–3385.
|
| [55] | Spain MM, Caruso JA, Swaminathan A, Pile LA (2010) Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem 285: 27457–27467.
|
| [56] | Miller M, Park MK, Hanover JA (1991) Nuclear pore complex: structure, function, and regulation. Physiol Rev 71: 909–949.
|
| [57] | Nakai K, Horton P (1999) PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem Sci 24: 34–36.
|
| [58] | Kosugi S, Hasebe M, Tomita M, Yanagawa H (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106: 10171–10176.
|
| [59] | Kalderon D, Roberts BL, Richardson WD, Smith AE (1984) A short amino acid sequence able to specify nuclear location. Cell 39: 499–509.
|
| [60] | Boulikas T (1994) Putative nuclear localization signals (NLS) in protein transcription factors. J Cell Biochem 55: 32–58.
|
| [61] | Nardozzi JD, Lott K, Cingolani G (2010) Phosphorylation meets nuclear import: a review. Cell Commun Signal 8: 32.
|
| [62] | Obenauer JC, Cantley LC, Yaffe MB (2003) Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res 31: 3635–3641.
|
| [63] | Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, et al. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66–71.
|
| [64] | Chen CF, Li S, Chen Y, Chen PL, Sharp ZD, et al. (1996) The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. J Biol Chem 271: 32863–32868.
|
| [65] | Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, et al. (2007) Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem 282: 5101–5105.
|
| [66] | Mason DA, Stage DE, Goldfarb DS (2009) Evolution of the metazoan-specific importin alpha gene family. J Mol Evol 68: 351–365.
|
| [67] | Dockendorff TC, Tang Z, Jongens TA (1999) Cloning of karyopherin-alpha3 from Drosophila through its interaction with the nuclear localization sequence of germ cell-less protein. Biol Chem 380: 1263–1272.
|
| [68] | Friedrich B, Quensel C, Sommer T, Hartmann E, Kohler M (2006) Nuclear localization signal and protein context both mediate importin alpha specificity of nuclear import substrates. Mol Cell Biol 26: 8697–8709.
|
| [69] | Giarre M, Torok I, Schmitt R, Gorjanacz M, Kiss I, et al. (2002) Patterns of importin-alpha expression during Drosophila spermatogenesis. J Struct Biol 140: 279–290.
|
| [70] | Mason DA, Fleming RJ, Goldfarb DS (2002) Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis. Genetics 161: 157–170.
|
| [71] | Mason DA, Mathe E, Fleming RJ, Goldfarb DS (2003) The Drosophila melanogaster importin alpha3 locus encodes an essential gene required for the development of both larval and adult tissues. Genetics 165: 1943–1958.
|
| [72] | Mathe E, Bates H, Huikeshoven H, Deak P, Glover DM, et al. (2000) Importin-alpha3 is required at multiple stages of Drosophila development and has a role in the completion of oogenesis. Dev Biol 223: 307–322.
|
| [73] | Ratan R, Mason DA, Sinnot B, Goldfarb DS, Fleming RJ (2008) Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis. Genetics 178: 839–850.
|
| [74] | Stark C, Breitkreutz BJ, Chatr-Aryamontri A, Boucher L, Oughtred R, et al. (2011) The BioGRID Interaction Database: 2011 update. Nucleic Acids Res 39: D698–704.
|
| [75] | Murali T, Pacifico S, Yu J, Guest S, Roberts GG 3rd, et al. (2011) DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila. Nucleic Acids Res 39: D736–43.
|
| [76] | Yu J, Pacifico S, Liu G, Finley RL Jr (2008) DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions. BMC Genomics 9: 461.
|
| [77] | Chan CC, Zhang S, Rousset R, Wharton KA Jr (2008) Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling. Dev Biol 318: 17–28.
|
| [78] | Gorjanacz M, Adam G, Torok I, Mechler BM, Szlanka T, et al. (2002) Importin-alpha 2 is critically required for the assembly of ring canals during Drosophila oogenesis. Dev Biol 251: 271–282.
|
| [79] | Mosca TJ, Schwarz TL (2010) The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat Neurosci 13: 935–943.
|
| [80] | Kussel P, Frasch M (1995) Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation. J Cell Biol 129: 1491–1507.
|
| [81] | Torok I, Strand D, Schmitt R, Tick G, Torok T, et al. (1995) The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. J Cell Biol 129: 1473–1489.
|
| [82] | Hanna-Rose W, Hansen U (1996) Active repression mechanisms of eukaryotic transcription repressors. Trends Genet 12: 229–234.
|
| [83] | Gray S, Levine M (1996) Transcriptional repression in development. Curr Opin Cell Biol 8: 358–364.
|
| [84] | Fisher AL, Caudy M (1998) Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev 12: 1931–1940.
|
| [85] | Carroll SB (1990) Zebra patterns in fly embryos: activation of stripes or repression of interstripes? Cell 60: 9–16.
|
| [86] | Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (2002) Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor. EMBO J 21: 2451–2460.
|
| [87] | Song CZ, Keller K, Chen Y, Stamatoyannopoulos G (2003) Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity. J Mol Biol 329: 207–215.
|
| [88] | Chen C, Agnès F, Gélinas C (1999) Mapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein. Cell Biol 19: 307–16.
|
| [89] | Perrimon N, McMahon AP (1999) Negative feedback mechanisms and their roles during pattern formation. Cell 97: 13–16.
|
| [90] | Freeman M (2000) Feedback control of intercellular signalling in development. Nature 408: 313–319.
|
| [91] | Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181–203.
|
| [92] | Hardin PE, Hall JC, Rosbash M (1990) Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343: 536–540.
|
| [93] | Allada R, Chung BY (2010) Circadian organization of behavior and physiology in Drosophila. Annu Rev Physiol 72: 605–624.
|
| [94] | Hogenesch JB, Ueda HR (2011) Understanding systems-level properties: timely stories from the study of clocks. Nat Rev Genet 12: 407–416.
|
| [95] | Dang DT, Zhao W, Mahatan CS, Geiman DE, Yang VW (2002) Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene. Nucleic Acids Res 30: 2736–2741.
|
| [96] | Rodríguez E, Martignetti JA (2009) The Krüppel traffic report: cooperative signals direct KLF8 nuclear transport. Cell Res 19: 1041–3.
|
| [97] | Tuncher A, Sprote P, Gehrke A, Brakhage AA (2005) The CCAAT-binding complex of eukaryotes: evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and human. J Mol Biol 352: 517–533.
|
| [98] | Blom N, Gammeltoft S, Brunak S (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 294: 1351–1362.
|
| [99] | Rihs HP, Peters R (1989) Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the Simian virus 40 T-antigen. EMBO J 8: 1479–1484.
|
| [100] | Mehta TS, Lu H, Wang X, Urvalek AM, Nguyen KH, et al. (2009) A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers. Cell Res 19: 1098–109.
|
| [101] | Chen G, Li W, Zhang QS, Regulski M, Sinha N, et al. (2008) Identification of synaptic targets of Drosophila pumilio. PLoS Comput Biol 4: e1000026.
|
| [102] | Tamanini F, Yagita K, Okamura H, van der Horst GT (2005) Nucleocytoplasmic shuttling of clock proteins. Methods Enzymol 393: 418–435.
|
| [103] | Miyazaki K, Mesaki M, Ishida N (2001) Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein. Mol Cell Biol 21: 6651–6659.
|
| [104] | Jans DA, Hubner S (1996) Regulation of protein transport to the nucleus: central role of phosphorylation. Physiol Rev 76: 651–685.
|
| [105] | Nicol JW, Helt GA, Blanchard SG Jr, Raja A, Loraine AE (2009) The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets. Bioinformatics 25: 2730–2731.
|
