A STUDY OF THE PHYSICOCHEMICAL CHARACTER OF THE INTERACTION OF THE LIPOSOME CONTAINING OLEIC ACID OF THE LIQUID-CRYSTAL STATE AND BIOMEMBRANE
液晶态油酸脂质体与生物膜相互作用的理化特性

The structure of the liquid crystal state of the new antiturner agent, polyphase liposome containing oleic acid, has been studied by small angle puiypnase scattering (SAXS) and 31P nuclear magnetism resomance (31P-NMR). Experimental results show that the presence of cholesterol, oleic acid, nonionic surfactant will highly affect the structure of the liquid crystal state of the PE liposome containing oleic acid. The liquid crystal state of liposome with oleic acid made from phosphoric buffer solution containing polyvinylpyrrolidone consists of both lamellar-hexagonal phase and lamellar-cubic phase. Electron-spin-resonance (ESR) experiment shows that the W/S value in the Ehrlich ascites tumor cell increases as the amount of liposome increases.