Effect of YXXM motif on viral replication of subgroup J avian leukosis virus
YXXM 基序对J 亚群禽白血病病毒复制的影响

Objective] It was reported that subgroup J avian leukosis virus strain NX0101 activates PI3K/Akt pathway during early infection in DF-1 cells.Whether there is YXXM motif in the amino acid sequence of NX0101 and the function of YXXM motif were studied.Methods] The presence of internal transmembrane domains in the envelope protein of NX0101 was analyzed by Tmpred.Point mutation was introduced to change the YXXM motif in the NX0101 strain to FXXA.The plasmid containing the full genome of NX0101 with mutation...