Homology modeling and molecular docking of xylitol dehydrogenase from Aspergillus Oryzae
米曲霉木糖醇脱氢酶的分子模建与对接

Objective]We investigated the structure model and function of xylitol dehydrogenase from Aspergillus oryzae.Methods] Xylitol dehydrogenase(XDH) gene from Aspergillus oryzae was cloned and sequenced.We constructed four tertiary structure models of XDH by homology modeling with Swiss-MODEL and Modeller and obtained the best quality model by evaluation of PROCHECK and Prosa2003.The dockings of NAD+,Zn2+ and xylitol with XDH were performed by Molsoft program.Results] Structure analysis suggested that XDH was...