Cholesterol-degrading in mice by Lactobacillus plantarum LpT1 and LpT2 in vivo
植物乳杆菌LpT1和LpT2大鼠体内降胆固醇特性

Objective]To explore the cholesterol-degrading in mice by Lactobacillus plantarum LpT1 and LpT2 in vivo.Methods] The hypercholesterolemia mice were randomly classified into 4 groups: A,B,C and D and fed with strain LpT1,LpT2,lovastatin and distilled water,respectively,and then TC,TG,HDL-C,LDL-C and AI were determined.The tissue slice of liver was made and observed by transmission electron microscope.Results] The hypercholesterolemia mice model was successfully constructed after feeding the hypercholesterol forage for 7 days.Lactobacillus plantarum LpT1 and the positive control lovastatin could significantly degrade the total cholesterol content(p<0.01) after 28 days,higher than Lactobacillus plantarum LpT2(p<0.05).However,the negative control water could not degrade it.The transmission electron microscope result showed that the strains could effectively regulate the lipid metabolism to develop towards the regular trend after they were absorbed into the intestines.Conclusion] The results further laid foundation for studying the cholesterol-degrading mechanism by Lactobacillus plantarum in vivo.