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微生物学报 1994
STUDIES ON THE DIFFERENTIATION AND PROPERTIES OF STREPTOMYCES ANSOCHROMOGENES
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Abstract:
S. ansochromogenes is a Nikkomycin producer which isolated from soil in northeast of China. It has typical differentiation properties on glucose-asparagine medium. After pre-germination spores were treated with NTG, seven white mutants (whi)were obtained, which could not produce mature grey spores, and also eight bald mutants (bld) could not produce aerial mycelium. After several generations, all mutants are stable, bld mutants and some of the whi mutants could not produce nikkomycin. It shows that the blocked genes function not only in morphological differentiation but also in antibiotic biosynthesis. 5. ansochromo genes is a suitable material for the study on molecular biology of differentiation, especially, the