Bioactive Substances from Cordyceps gunnii I. Separation,Purification and Properties of Analgesic Substance
古尼虫草的生物活性物质I含肽镇痛组分的分离及性质

The analgesic substance from mycelia of Paecilomyces gunnii Liang that is anamorph of Cordyceps gunnii(Berk.)Berk. was isolated and purified by combined with separation and analyzing and biology experiment. Based on the results by amino acid analyzer showed that the analgesic substance from P.gunnii is not dissociate amino acid but a bioactive peptide consisting of more acidic amino acids .The analgesic bioactive substance was stable to acids and host under acidic condition. It was not sensitive to proteinase K and partly sensitive to pepsin and trypsin. By animal tests of Mus musculus and Rattus norxegius showed the analgesic bioactive substance have no drug addiction being similar to morphia.