Choline of Pneumococcal Cell Wall Mediated Streptococcus pneumoniae Invasion to Activated HUVEC
肺炎链球菌磷壁酸胆碱成分介导细菌的侵袭

To study the effect of the choline in pneumococcal cell wall on its invasion of HUVEC. By invasion experiment to examine the invasion rate of activated HUVEC by S.pneumoniae, when pneumococcus were administrated with BN52021, which is a platelet-activating factor receptor (PAF-R) antagonist or choline in pneumococcal culture was substituted with ethanolamine. It was observed that platelet activating factor receptor antagonist BN52021 and the substitution of choline with ethanolamine in culture blocked the invasion to HUVEC. It was demonstrated that the choline in pneumococcal cell wall was the critical site of pneumococci binding to PAF-R. And pneumococci invade HUVEC with the PAF-R internalization.