Antifungal susceptibility test of Paecilomyces hepiali by CLSI M38-A2 broth dilution method
CLSI M38-A2肉汤稀释法对蝙蝠蛾拟青霉(Paecilomyces hepiali)的药敏检测

Objective] To test filamentous fungi antifungal susceptibility,this study determined the minimal inhibitory concentration(MIC) values of 6 antifungal agents: Itraconazole(ITC),Ketoconazole(KET),Voriconazole(VRC),Ciclopirox(CIC),5-Flurocytosine(5FC),Fluconazole(FLU) to the strain Paecilomyces hepiali which usually used in health food industry.Methods] Method of Clinical Laboratory Standards Institute(CLSI) M38-A2 was referred.Results] The results showed that the quality control strain Candida parapsilosis ATCC 22019T MIC values were within the reference range,the strain P.hepiali MIC values for the 6 antifungal agents were 1 mg/L,0.5 mg/L,0.25 mg/L,≥128 mg/L,64 mg/L,2 mg/L respectively.Conclusion] M38-A2 method could be applied to determine the susceptibility of P.hepiali to antifungal agents.But,more tests needed to acquire the standard interpretation of the strains susceptibility.