L-LACTIC ACID FERMENTATION AND COUPIED WITH ION-EX- CHANGE SEPARATION IN A THREE-PHASE FIUIDIZED-BED BIOREACTOR
三相流化床L-乳酸发酵及与离子交换分离耦合

The L-lactic acid production with R. oryzae immobilized by calcium alginate entrapment method was studied. A three-phase fluidized-bed bioreactof was developed. Comparing to free-cell fermentation, high productivity (3-4g . L-1 . h-1) and yield (0.77-0.80g/g)was obtained. The simultaneous fermentation and ion-exchange separation was studied to overcome some shortages in the conventional fermentation process with CaCO3 as the neutralizer, and the process was proved feasible to product L-lactic acid efficiently.