Application of Multilocus Sequence Typing method on Pathogenic Microorganisms Typing and Identification
多位点测序分型技术在病原微生物分型鉴定中的应用

It is important for identifying,tracking and preventing pathogenic microorganism's outbreak in the epidemiology of infectious diseases.Establish a useful simple method for typing and identifying pathogenic microorganisms is necessary.In 1998,Multilocus sequence typing was proposed which is a nucleotide sequence based approach.It combined developments in high-throughput sequencing techniques with established population genetics.This typing method is a portable and reproducible typing system which can track and investigate pathogenic microbes distributed condition over the global by the internet.Now,MLST schemes have been developed for a variety of prokaryotic and some eukaryotic pathogens(like some fungus).In this paper,the theory of MLST and its application on some pathogenic microbes typing and identifying were introduced.