Comparison of Toxic and Pharmacological Action among Radix Aconiti with Different Preparations
附子乌头草乌及其炮制品的毒效比较

The study is aimed to compare toxicity of aconite roots in different preparations from the point of both toxic and pharmacological action.Related experiment basis was presented in the study and research of Chinese medicinal.Toxicity,morbidity and minimum cardiac toxic dose were assessed.Effects on acetic acid-induced abdominal constriction and trichloromethane-induced ventricular fibrillation of mice were observed.The results showed that from the morbidity of acute toxicity,the toxicity of refined aconite roots is reduced with the maximum tolerance dosage of 20.52 g/kg,except the aconite root prepared by salt(LD50 11.301 g/kg).Base on the clinic index(toxic dose/effective dose),the safety index of the root by different preparation were,from big to small,by boiling plus steaming was more than only by boiling preparation,which is more than only salt preparation without boiling and steaming,respectively.The toxicity of Aconitum kusnezoffii Reichb.(Cao Wu) was more than LD50 292.38 mg/kg.But,its toxicity was apparently reduced to 70.32 times through preparation.It is concluded that by the process of refining aconites,the result of toxicity-reducing and action-maintaining was for refined Aconitum carmichaeli Debx.Actions were attenuated in both toxicity and pharmacology in refined Aconitum kusnezoffii Reichb.