Evaluation on Preparation and Release Characteristics of Ginkgolides Gastric Floating Sustained-Release Tablets in Vitro
银杏内酯胃漂浮片制备及体外释放度评价

The method of preparing Ginkgolides gastric floating sustained-release tablet was studied and the releasing characteristics in vitro were also investigated.The floating and releasing performance in vitro were used as indicators to evaluate and optimize the formulation.Effects of hydroxypropyl methyl cellulose(HPMC) type and amount,sodium bicarbonate amount and stearic acid amount on release behavior in vitro were observed in single-factor testing method.Then the formulation was optimized by orthogonal design test to determine the best preparation technological conditions.The result showed that gastric floating sustained-release tablets,which were prepared with HPMCK4M as matrix,stearic acid as floating assistant,sodium bicarbonate as gas-producer,and microcrystalline cellulose and lactose as fillers,was taken once a day.And the tablet was released 35% in 2 h,60% in 6 h,exceeding 85% in 12 h.The releasing rate met requirements for gastric floating sustained-release.It is concluded that ginkgolides gastric floating sustained-release tablets prepared in this method has good release characteristics.The tablets are in good shape and compressibility.The preparative technology is also simple with low manufacture cost.