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世界科学技术-中医药现代化 2010
The Content of Sex Hormone and Regulation Hormone in the Peripheral Blood and Different Encephalic Regions of Premens-trual Syndrome Liver-qi Invasion and Liver-qi Depression Model Rats
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Abstract:
PMS liver-qi invasion/depression rat models were established to detect the monoamine neurotransmitter content in sera and in different encephalic regions, thus exploring the possible mechanism of "liver losing regulation". 40 rats in the non-receptive phases were selected and randomly divided into 5 groups: the normal control group, the PMS liver-qi invasion group, the PMS liver-qi depression group, the PMS liver-qi invasion medication administration group, and the PMS liver-qi depression medication administration group. With the multiple factor combination method, emotion stimulation was given to prepare the PMS liver-qi invasion rat model, and chronic constraint stimulation was given to prepare the PMS liver-qi depression rat model. Then Jingqianping granules were administrated to the PMS liver-qi invasion rats, and Jingqianshu granules to the PMS liver-qi depression rats. The E2, P and PRL content in sera and in different encephalic regions were determined using the radioimmunity method. In the open-field experiment, the liver-qi invasion rats got much higher scores than the control rats, while the liver-qi depression rats got significantly decreased scores. This trend was retrieved after administration. Liver-qi invasion rats showed a descending tendency for the E2,P contents, and the liver-qi depression rats had a similar change in sera in the period of symptom presentation. A contradictory situation appeared in the center. These results indicated that PMS symptom emergence is likely related to the abnormal fluctuation in vivo of sex hormone and regulation hormone, and the two medicines aforementioned may cure the diseases by regulating the above abnormal changes.
