Comparative Study on the Effect of the Tranquilizer of Zhongzhen Anshen and Yangxin Anshen on Insomnia Rats in the Sleeping Phase
养心安神药与重镇安神药对失眠大鼠睡眠时相影响的比较研究

This work aimed to compare and analyze the effect of the tranquilizer of Zhongzhen Anshen and Yangxin Anshen. Polysomnography was used to record the changes of EEG and EMG in rats at different sleeping phases. The influences of Yangxin Anshen and Zhongzhen Anshen on EEG and EMG were observed. Baiziren and Yuanzhi of Yangxin Anshen increased SWS1. Suanzaoren of Yangxin Anshen increased SWS1 and SWS2. Cishi and Zhusha of Zhongzhen Anshen both prolonged SWS1, SWS2 and REMS. Taken together, Yangxin Anshen and Zhongzhen Anshen have distinct effects on ofinsomnia rats at the sleeping phase. Zhongzhen Anshen could prolong REMS, but Yangxin Anshen could not. Cishi and Zhusha of Zhongzhen Anshen could markedly prolong SWS of insomnia rats, thus better improving the sleep quality of insomnia rats.