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世界科学技术-中医药现代化 2011
Brain-Smooth Muscle Axis: A Hypothesis and Its Interrelation with the Liver Visceral Manifestation Theory of Traditional Chinese Medicine or Comorbid Depression
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Abstract:
Brain-smooth muscle(BSM) axis refers to a bidirectionally influence and modulatory pathway between encephalic region and smooth muscle.Via local cytochrome P450 enzyme and endogenous active material,stress reaction between brain and vascular or visceral smooth muscle were modulated,specially implicated depressive comorbidities.Evidence provided by publications and recent experiments of this research group showed that firstly 40-50% depression is comorbidity of functional gastrointestinal disorders;a frequent comordibity of functional hypothalamus amenorrhea and depression;depression increases a 3 to 6 fold of nocturia than healthy people;myocardial and cerebral ischemia induce depression.Comorbidity mentioned above specially implicated simultaneous disorders of brain and vascular or visceral smooth muscle.Secondly,a traditional Chinese medicine formula is simultaneously effective as an anti-depressive,prokinetic and vasoactive,which highlights the therapeutic mechanism of modern anti-depressive serotonin and noradrenaline reuptake inhibitor.Absorbed bioactive compounds in hippocampus,intestine and vessel wall were detected after oral administration of the formula and forced swimming rat.Thirdly,both sides of BSM axis are the same,suggesting the common pathophysiological mechanism.Among four axes,only "brain",one side of axis,is the same and other sides are different.Fourthly,the pivotal role is that one of the important pathogenetic mechanisms on liver visceral manifestation of TCM theory and stress disease is the disorder of BSM axis.The validation and improvement of BSM axis hypothesis contribute much to the study of depression,stress diseases and liver visceral manifestation in TCM.