Ideas and Methods in Study of Traditional Chinese Medicine by Capturing System of High Through - put Molecules
高通量分子捕捉系统研究中药的思路与方法

Objective: To explore ideas and methods in the study of traditional Chinese medicine by the capturing system of high through - put molecules. Method: To analyze the specially capturing functions of a simple system of unitary protein molecules on the active molecules in the compound of Chinese medicines on the basis of the characteristics which the simple molecular system and complex bio - system possess in their capture of and response to signal molecule. The change of signals emerging when protein molecules capture active molecules can be shown by the detecting system and be analyzed easily. Therefore, the molecule - capturing system made up by protein molecules as its basic components is able to form around 500 types of protein - targeting molecules involved in the mechanisms of all drugs into capturing arrays of high through - put molecules, which are suitable to analyses and studies. As a result Chinese herbal medicines can afford to be studied in an all - round way. Result: The processing technology, the capturing arrays of high through - put molecules, high through - put detecting technology and the automatically data - processing systems used in Chinese medicinal materials can be integrated into a high through - put molecule - capturing system which can break the barriers existing in the present methodology of studies so as to promote the study of traditional Chinese medicine in many ways. Conclusion: The study of Chinese medicines through high through - put molecule - capturing system is able to break restrictions in methodology applied in the current studies of Chinese drugs. It is necessary, however, to do plenty of work before such a system is put into practice.