Therapeutic Effect of Kaixin Jieyu Decoction on the Behavior and Cerebral Blood Flow of Bilateral Carotid Artery-Ligated in Rats
开心解郁汤对双侧颈总动脉结扎大鼠行为学及脑血流量的影响

This work aimed to investigate the effect of Kaixin Jieyu Decoction on the behavior and cerebral blood flows of permanent bilateral carotid artery-ligated rats. The bilateral carotid artery-ligated rats were used as the animal models. By laser Doppler flowmetry detection, the rat frontal and parietal cerebral blood flow (CBF) were determined. The rat memory function was detected by the Morris water maze. Three days after administration of Kaixin Jieyu, the rat frontal and parietal CBF, as well as memory, of the experimental group were improved, but with no statistic significance. The results show that Kaixin Jieyu Decoction has some therapeutic effect on rat permanent cerebral ischemia caused by bilateral carotid artery ligation, but further investigation is needed.